Parkinson's disease, affecting 6.1 million worldwide, poses a significant challenge due to its progressive nature and limited treatment options. The disease is characterized by the loss of dopaminergic neurons and the accumulation of phosphorylated alpha-synuclein, yet the molecular mechanisms remain elusive. In our research, we have discovered a potential connection between Parkinson's and the NFE2L1 gene, known for regulating cellular stress, including the ubiquitin-proteasome system. NFE2L1 is highly expressed in healthy dopaminergic neurons, but in Parkinson's patients, its expression is known to be drastically reduced. This points to a possible association between NFE2L1 loss in dopaminergic neurons and Parkinson's onset, though direct evidence is lacking and warrants further investigation. Understanding the role of NFE2L1 in dopaminergic neurons could provide insights into Parkinson's pathology, as currently, not many functional studies exist. Unraveling these mechanisms is crucial for developing effective prevention and management strategies for this prevalent neurodegenerative disorder.